Q1 — 2017 :
Chapter 03
Best Cities, Lifelong Wellness, and Productive Retirement
Negative Age Stereotypes Predict Alzheimer's Disease Biomarkers
Becca Levy and others
February 01, 2016

Although negative age stereotypes have been found to predict adverse outcomes among older individuals, it was unknown whether the influence of stereotypes extends to brain changes associated with Alzheimer’s disease. To consider this possibility, we drew on the age stereotypes of dementia-free participants in the Baltimore Longitudinal Study of Aging that had been measured decades before yearly MRIs and brain autopsies were performed. Those with more negative age stereotypes earlier in life had significantly steeper hippocampal-volume loss, and significantly greater accumulation of neurofibrillary tangles and amyloid plaques at autopsy, adjusting for relevant covariates. These findings suggest a new pathway to identifying mechanisms and potential interventions related to the neuropathology of Alzheimer’s disease.

Q1 — 2017 : Chapter 03 > Negative Age Stereotypes Predict Alzheimer's Disease Biomarkers by Becca Levy and others